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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
Published on: February 7, 2021
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Controlled release of therapeutics using interpenetrating polymeric networks
Tejraj M Aminabhavi1, Mallikarjuna N Nadagouda, Uttam A More
1Soniya College of Pharmacy, Department of Pharmaceutical Engineering and Chemistry , S.R. Nagar, Dharwad 580 002 , India +91 9449821279 ; +91 836 2467190 ; aminabhavi@yahoo.com ; aminabhavit@gmail.com.
Expert Opinion on Drug Delivery
|October 25, 2014
Summary
Biodegradable polymers, including interpenetrating networks (IPNs) and semi-IPNs, are crucial for controlled drug release. These smart hydrogels offer tunable release profiles influenced by environmental factors and are effective for various medications.
Area of Science:
- Polymer Science
- Materials Science
- Pharmaceutical Science
Background:
- Biodegradable polymers are increasingly vital in pharmaceutical formulations.
- Interpenetrating networks (IPNs) and semi-IPNs are gaining importance for controlled drug delivery.
- These advanced polymer structures enable sophisticated drug release mechanisms.
Purpose of the Study:
- To review the preparation methods of IPNs and semi-IPNs.
- To analyze the controlled release (CR) properties of these polymer systems.
- To highlight their application in delivering various therapeutic agents.
Main Methods:
- Preparation of IPNs and semi-IPNs using chemical or physical crosslinking.
- Development of smart hydrogels with tunable properties.
- Characterization of drug release kinetics influenced by pH and temperature.
Main Results:
- IPNs and semi-IPNs demonstrate remarkable drug release patterns.
- Release profiles are significantly influenced by environmental factors like pH and temperature.
- These systems show superior performance compared to single polymer systems.
Conclusions:
- IPNs and semi-IPNs are innovative materials for controlled drug release.
- Their tunable nature makes them suitable for a wide range of drugs, including anticancer, anti-asthmatic, and antibiotics.
- Further research into their preparation and CR properties is warranted.
Keywords:
controlled releasehydrogelsinterpenetrating networksmicrospheressemi-interpenetrating networksMore Related Videos
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