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Published on: November 5, 2019
[Clinical, epidemiological, and etiological studies of aseptic meningitis in adults]
Shinichi Takeshima1, Shuichiro Neshige, Takahiro Himeno
1Department of Neurology, Brain Attack Center, Ota Memorial Hospital.
Abstract:
From summer to autumn, we noted the occurrence of a small epidemic of aseptic meningitis in adults. Over the last 10 years, we have encountered 203 male (mean age, 34.6 ± 15.0 years) and 157 female (mean age, 35.6 ± 16.3 years) patients with aseptic meningitis. We could identify the causative virus in 17 (81%) of 21 cases during the abovementioned months in 2012. Identification rates of the virus in the stool, cerebrospinal fluid, throat swab, and serum samples were 71%, 67%, 42%, and 5%, respectively. The etiological viruses included enteroviruses in all cases, such as echovirus type 9 (E9) in 9 cases, echovirus type 6 (E6) in 4 cases, coxsackievirus type A9 in 1 case, and unknown type of enterovirus in 3 cases. No differences in the clinical manifestations and laboratory findings were noted between E9 meningitis and E6 meningitis. In addition, we countered 14 cases of mumps meningitis, 7 cases of varicella-zoster virus meningitis and 6 cases of herpes simplex meningitis during the last 10 years; these cases did not occur as an epidemic, but occurred sporadically. Cases of mumps meningitis were noted in all seasons, and cases of varicella-zoster virus meningitis were only noted from summer to winter. The etiology of epidemic aseptic meningitis in adults could be mainly due to enterovirus infection, and its prognosis was benign.
Insights
Aseptic meningitis epidemics in adults are primarily caused by enteroviruses, particularly echovirus types 9 and 6. These infections, often occurring in summer and autumn, generally have a favorable prognosis.
Area of Science:
- Infectious Diseases
- Neurology
- Virology
Context:
- Aseptic meningitis is a significant cause of neurological illness in adults.
- Epidemic occurrences of aseptic meningitis have been observed, particularly during warmer months.
- Enteroviruses are a common cause of viral meningitis.
Purpose:
- To investigate the etiological agents and epidemiological patterns of aseptic meningitis in adults.
- To identify the specific enteroviruses responsible for epidemic aseptic meningitis.
- To compare clinical and laboratory findings between different enteroviral meningitis types.
Summary:
- A 10-year study identified aseptic meningitis in 360 adults, with a small epidemic in summer/autumn 2012.
- Enteroviruses, including echovirus types 9 and 6, were the primary cause of epidemic aseptic meningitis.
- Sporadic cases of mumps, varicella-zoster, and herpes simplex virus meningitis were also noted.
Impact:
- Highlights enteroviruses as the main etiological agents for adult aseptic meningitis epidemics.
- Provides insights into the seasonal patterns and viral identification rates for aseptic meningitis.
- Confirms the generally benign prognosis of enteroviral meningitis in adults.
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