[Structural-functional properties of erythrocyte membranes in patients with infectious-allergic bronchial asthma]

A decrease in activity of Ca2(+)-ATPase and activation of Na+, K(+)-ATPase, correlating with elevation in content of phosphatidyl inositol and phosphatidyl serine, were detected in erythrocyte membranes of patients with the infectional-allergic form of bronchial asthma. Microviscosity of the erythrocyte membranes, estimated by fluorescence spectra of pyrene, was not altered, while negative charge as shown by ANS- fluorescence, was slightly increased on the membrane surface. Euphylline, intal, levamizole and glucocorticosteroid were found to regulate the ATPases activity in vivo and in vitro.