[Permeability for 45Ca and Ca-ATPase activity in erythrocyte membranes of patients with psoriasis]

Accumulation of 45Ca in erythrocytes was 1.6-fold higher in presence of vanadate in patients with psoriasis as compared with healthy persons. This difference was maintained within 24 hrs of the heparinized blood storage, although penetration of Ca2+ through erythrocyte membranes was increased by about 67% both in patients and in healthy persons. Maximal activity of Ca2(+)-ATPase in erythrocyte membranes, measured in presence of endogenous regulators, was near normal values in the majority of the patients (15-300 microM P/L er. min) and above normal values--in 18% of the patients (320-420 microM P/L er. min). The data obtained suggest that systemic impairments of membrane transport of Ca2+ are of importance for pathogenesis of psoriasis.