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Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid
Published on: September 20, 2017
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Solubility and dissolution enhancement strategies: current understanding and recent trends
Shashank Jain1, Niketkumar Patel, Senshang Lin
1College of Pharmacy and Health Sciences, St. John's University , Queens, NY , USA.
Drug Development and Industrial Pharmacy
|October 25, 2014
Summary
Lipophilic drug compounds often exhibit poor aqueous solubility, hindering absorption and increasing drug development costs. This review revisits solubility concepts to guide the selection of effective pre-formulation and formulation strategies for improved drug delivery.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery
- Physical Chemistry
Background:
- High-throughput screening frequently identifies lead compounds with high molecular weight and poor aqueous solubility.
- Poor aqueous solubility of lipophilic compounds impedes dissolution, absorption, and increases drug development costs.
- Existing pre-formulation and formulation strategies struggle to consistently overcome solubility challenges.
Purpose of the Study:
- To revisit theoretical and mathematical concepts of solubility and dissolution.
- To provide guidance on selecting appropriate pre-formulation and formulation strategies.
- To review recent research in solubility enhancement over the past decade.
Main Methods:
- Review of fundamental principles of solubility and dissolution.
- Analysis of strategies for manipulating crystal lattice properties and activity coefficients.
- Literature survey of research on solubility enhancement techniques.
Main Results:
- A deeper conceptual understanding of solubility is crucial for effective strategy selection.
- Theoretical frameworks can guide rational decisions in pre-formulation and formulation.
- The review synthesizes current knowledge and highlights research trends in the field.
Conclusions:
- Addressing poor aqueous solubility requires a strong theoretical foundation.
- Rational selection of strategies based on solubility principles can optimize drug development.
- Continued research is essential to overcome persistent solubility challenges in drug discovery.
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