Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Embryonic Stem Cells00:57

Embryonic Stem Cells

4.5K
Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
4.5K
Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

6.0K
The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
6.0K
Cellular Differentiation00:57

Cellular Differentiation

5.6K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
5.6K
Cleavage and Blastulation01:33

Cleavage and Blastulation

42.1K
After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
42.1K
Determination01:51

Determination

16.3K
During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
16.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reprogramming of TLR-Ferroptosis Signaling and Immunometabolic Pathways Overcomes Myeloid Suppression to Improve Checkpoint Blockade in Prostate Cancer.

Cancer research·2026
Same author

RAB5c orchestrates LC3-associated phagocytosis to promote microbicidal function of macrophages.

Science advances·2026
Same author

Ferroptosis induces heterogeneous death profiles that are controlled by lysosome rupture.

Developmental cell·2026
Same author

An ultrasmall core-shell silica nanoparticle improves antitumour immunity and survival by remodelling suppressive melanoma microenvironments.

Nature nanotechnology·2025
Same author

The RNA-binding protein RNP1A is essential and interacts with contractility kit proteins to facilitate cell mechanics.

Journal of cell science·2025
Same author

Entosis in Health and Disease.

Advances in experimental medicine and biology·2025
Same journal

Galvanin: a molecular compass for bioelectric navigation.

Cell research·2026
Same journal

Why microglial repair programs fade.

Cell research·2026
Same journal

Atypical signaling, ligand recognition and selective agonist discovery of complement receptor C5aR2.

Cell research·2026
Same journal

One drug, five targets.

Cell research·2026
Same journal

Smooth emotional response: amygdalar neurovascular coupling drives stress encoding.

Cell research·2026
Same journal

Liquid surrogates of spatial tumor ecosystems.

Cell research·2026
See all related articles

Related Experiment Video

Updated: Apr 21, 2026

Innervation of Human Intestinal Organoids
07:23

Innervation of Human Intestinal Organoids

Published on: January 17, 2025

1.3K

Competition between human cells by entosis.

Qiang Sun1, Tianzhi Luo2, Yixin Ren2

  • 11] Laboratory of Cell Engineering, Institute of Biotechnology, Beijing 100071, China [2] Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

Cell Research
|October 25, 2014
PubMed
Summary
This summary is machine-generated.

Human tumor cells compete directly through entosis, a process where one cell engulfs another. Mechanical properties, like deformability, determine which cells survive and which are eliminated in this "winner-take-all" competition.

More Related Videos

Fate Mapping of Human Embryonic Stem Cells by Teratoma Formation
08:56

Fate Mapping of Human Embryonic Stem Cells by Teratoma Formation

Published on: August 1, 2010

18.7K
Progenitor-derived Oligodendrocyte Culture System from Human Fetal Brain
14:26

Progenitor-derived Oligodendrocyte Culture System from Human Fetal Brain

Published on: December 20, 2012

14.1K

Related Experiment Videos

Last Updated: Apr 21, 2026

Innervation of Human Intestinal Organoids
07:23

Innervation of Human Intestinal Organoids

Published on: January 17, 2025

1.3K
Fate Mapping of Human Embryonic Stem Cells by Teratoma Formation
08:56

Fate Mapping of Human Embryonic Stem Cells by Teratoma Formation

Published on: August 1, 2010

18.7K
Progenitor-derived Oligodendrocyte Culture System from Human Fetal Brain
14:26

Progenitor-derived Oligodendrocyte Culture System from Human Fetal Brain

Published on: December 20, 2012

14.1K

Area of Science:

  • Cell biology
  • Cancer research
  • Biophysics

Background:

  • Tumor cells compete for resources, but direct elimination mechanisms are unknown.
  • Understanding cell competition is crucial for cancer biology.

Purpose of the Study:

  • Investigate direct competition mechanisms between human tumor cells.
  • Identify the factors governing cell engulfment and survival in tumors.

Main Methods:

  • Studied entosis, a cell engulfment process.
  • Analyzed mechanical properties (deformability) and signaling pathways (RhoA, actomyosin, Kras, Rac).
  • Computed energy landscapes of cell-in-cell formation.

Main Results:

  • Identified entosis as a direct cell competition mechanism.
  • Demonstrated that higher cell deformability, regulated by RhoA and actomyosin, confers a "winner" status.
  • Showed that Kras and Rac signaling promote "winner" status by downregulating myosin.
  • Established that a mechanical differential between cells is essential for entosis.

Conclusions:

  • Entosis is a mechanism of direct competition in human tumors.
  • Cellular mechanical properties and signaling pathways dictate competitive outcomes.
  • This study reveals a novel aspect of tumor cell interaction and survival.