Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Oogenesis02:07

Oogenesis

68.8K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
68.8K
Epithelial Tissues and Their Functions01:23

Epithelial Tissues and Their Functions

37.3K
Epithelial tissues are large sheets of cells covering all of the surfaces of the body. These surfaces can be internal or external, for example, skin, airways, the digestive tract, the urinary system, and the reproductive system. Hollow organs and body cavities that do not connect to the body's exterior, including blood vessels and serous membranes, are lined by epithelial tissue known as the endothelium.
Epithelial tissues provide the body's first line of protection from physical,...
37.3K
Tight Junctions01:29

Tight Junctions

6.8K
Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments in multicellular organisms. They are mainly composed of claudin and occludin transmembrane proteins, and other proteins such as tricellulin and JAM (junctional adhesion molecule). All these proteins are 4-pass transmembrane proteins, except JAM, which is a single-pass transmembrane protein belonging to the immunoglobulin superfamily. The...
6.8K
Concepts of Health and Illness01:29

Concepts of Health and Illness

16.9K
Health is a condition of the body, mind, and spirit where an individual remains free from illness. Similarly, wellness is an active state, including living a lifestyle that promotes physical, mental, and emotional health. Physical health is critical for the overall well-being and can be affected by lifestyle, activity level, diet, and behavior. The highest attainable standard of health is a fundamental and universal human right. Consider Lisa, a fifteen-year-old born with congenital...
16.9K
Physiology of Enteric Nervous System and Gut Health01:05

Physiology of Enteric Nervous System and Gut Health

818
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
818
Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

3.8K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reprogramming of TLR-Ferroptosis Signaling and Immunometabolic Pathways Overcomes Myeloid Suppression to Improve Checkpoint Blockade in Prostate Cancer.

Cancer research·2026
Same author

Ferroptosis induces heterogeneous death profiles that are controlled by lysosome rupture.

Developmental cell·2026
Same author

An ultrasmall core-shell silica nanoparticle improves antitumour immunity and survival by remodelling suppressive melanoma microenvironments.

Nature nanotechnology·2025
Same author

ATG16L strikes again! New findings link lysosome stress and physiology.

The Journal of cell biology·2025
Same author

WNK1 mediates M-CSF-induced macropinocytosis to enforce macrophage lineage fidelity.

Nature communications·2025
Same author

Getting PIKy with the lysosome membrane (again).

Autophagy reports·2025
Same journal

Mammalian Respiratory Chain Complex Assemblies and Their Links to Mitochondria Stress-Induced Human Diseases.

Advances in experimental medicine and biology·2026
Same journal

Enzyme Assemblies in Nucleotide Metabolism: Structure, Regulation, and Disease Implications.

Advances in experimental medicine and biology·2026
Same journal

The Pyruvate Dehydrogenase Complex: A 90-Year-Old Enigma Shaping the Future of Structural Enzymology.

Advances in experimental medicine and biology·2026
Same journal

Regulation of the Anti-termination RNA Transcription Complex by Lon-Mediated Lambda N Degradation.

Advances in experimental medicine and biology·2026
Same journal

PCNA Macromolecular Complexes: PCNA Serves as a Molecular Hub Regulating Multiple Cellular Processes Inside and Outside of the Nucleus.

Advances in experimental medicine and biology·2026
Same journal

Dynamic Assemblies in Genome Maintenance.

Advances in experimental medicine and biology·2026
See all related articles

Related Experiment Video

Updated: Jan 6, 2026

Innervation of Human Intestinal Organoids
07:23

Innervation of Human Intestinal Organoids

Published on: January 17, 2025

1.0K

Entosis in Health and Disease.

Jyotirekha Das1, Michael Overholtzer2,3

  • 1Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Advances in Experimental Medicine and Biology
|September 26, 2025
PubMed
Summary
This summary is machine-generated.

Entosis is a cell-in-cell phenomenon where high-tension cells are engulfed by low-tension cells, often leading to cell death. This process is triggered by cellular stress and occurs in both normal and cancerous tissues.

Keywords:
Adherens junctionsAutophagyE-cadherinEntosisEntotic cell deathLysosomeROCKRho

More Related Videos

Establishment and Histological Analysis of Esophageal Organoids Modeling the Progression from Normal to Cancerous Tissues
05:57

Establishment and Histological Analysis of Esophageal Organoids Modeling the Progression from Normal to Cancerous Tissues

Published on: May 30, 2025

920
Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
07:00

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

6.2K

Related Experiment Videos

Last Updated: Jan 6, 2026

Innervation of Human Intestinal Organoids
07:23

Innervation of Human Intestinal Organoids

Published on: January 17, 2025

1.0K
Establishment and Histological Analysis of Esophageal Organoids Modeling the Progression from Normal to Cancerous Tissues
05:57

Establishment and Histological Analysis of Esophageal Organoids Modeling the Progression from Normal to Cancerous Tissues

Published on: May 30, 2025

920
Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
07:00

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

6.2K

Area of Science:

  • Cell Biology
  • Cell Death Mechanisms
  • Cell Engulfment Processes

Background:

  • Entosis is a unique cell-in-cell formation process distinct from phagocytosis.
  • It involves differential cell tension and adherens junction formation.
  • Entosis can lead to the death of the internalized cell or other outcomes like cell release.

Purpose of the Study:

  • To elucidate the mechanism of entosis.
  • To compare entosis with other cell death and engulfment pathways.
  • To discuss the role of entosis in various biological contexts.

Main Methods:

  • Review of existing literature on entosis.
  • Comparative analysis of entosis with phagocytosis and other cell death forms.
  • Discussion of factors influencing entosis, such as cell tension and stress.

Main Results:

  • Entosis engulfs high-tension cells into low-tension cells via adherens junctions.
  • Internalized cells typically undergo death, but alternative fates exist.
  • Entosis is induced by cellular stressors and observed in diverse tissues, including cancer.

Conclusions:

  • Entosis represents a distinct cell death and engulfment pathway.
  • Understanding entosis provides insights into cellular responses to stress.
  • Its occurrence in cancer highlights potential roles in tumor biology.