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DNA translocations through solid-state plasmonic nanopores.

Francesca Nicoli1, Daniel Verschueren, Misha Klein

  • 1Department of Bionanoscience, Kavli Institute of Nanoscience, Delft University of Technology , Lorentzweg 1, 2628 CJ Delft, The Netherlands.

Nano Letters
|October 28, 2014
PubMed
Summary
This summary is machine-generated.

This study demonstrates plasmonic nanopores enhance DNA translocation rates in lithium chloride (LiCl) solutions by 10-fold. This breakthrough overcomes low event rates, enabling precise DNA analysis with nanopore sensors.

Keywords:
DNANanoporesbiosensingplasmonicssingle-molecule sensingthermophoresis

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Area of Science:

  • Biophysics
  • Nanotechnology
  • Analytical Chemistry

Background:

  • Nanopores offer label-free detection of single biomolecules.
  • Solid-state nanopores are crucial for biomolecule analysis.
  • Plasmonic nanoantennas can enhance optical and sensing properties.

Purpose of the Study:

  • Investigate DNA translocation through a novel plasmonic nanopore.
  • Evaluate the effect of plasmonic excitation on DNA capture and translocation.
  • Enhance the low event rates of DNA translocation in lithium chloride (LiCl) buffers.

Main Methods:

  • Fabrication of a plasmonic nanopore using a gold bowtie nanoantenna and a solid-state nanopore.
  • Utilizing plasmonic excitation at the nanopore hot spot.
  • Measuring nanopore ionic conductance blockade during DNA translocation events.
  • Analyzing DNA translocation rates and durations under varying laser power in LiCl.

Main Results:

  • Plasmonic excitation influences DNA capture and sensor signal but not translocation duration.
  • A significant plasmon-induced enhancement (10-fold) of DNA translocation event rates in LiCl was observed.
  • Enhancement was achieved at low laser power (few mW).

Conclusions:

  • Plasmonic nanopores can dramatically increase DNA translocation event rates in LiCl.
  • The observed enhancement is attributed to plasmon-induced local heating and thermophoresis.
  • This technology enables efficient DNA analysis using nanopores in low-conductivity buffers.