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Updated: Apr 21, 2026

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
[Simultaneous treatment of HIV and tuberculosis is possible and necessary]
Sarah von der Maase1, Jan Gerstoft, Christian Wejse
1Vestervang 9, 971, 8000 Aarhus C. sarah_-vdm@hotmail.com.
Abstract:
The proper timing of antiretroviral therapy (ART) to HIV-patients co-infected with tuberculosis has been debated. We review three studies on this matter. One study found a significant reduced mortality for patients with CD4+ T-cell counts (CD4+) ≤ 200 per mm3 who received ART early, whereas the other two studies found this difference for patients with CD4+ < 50 per mm3.The risk of immune reconstitution inflammatory syndrome was significantly increased for the patients receiving ART early, but this contributed only to a small fraction of deaths related to HIV after the initiation of ART.
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