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Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
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Galectin-1 and immune suppression during radiotherapy
James W Welsh1, Steven N Seyedin2, Maria Angelica Cortez2
1Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. jwelsh@mdanderson.org.
Abstract:
Radiotherapy induces galectin-1 (Gal-1) secretion by tumors, which induces CD8(+) T-cell apoptosis and lymphopenia. These effects are substantially decreased by Gal-1 shRNA. Inhibition of Gal-1 may be an effective strategy for overcoming radiation-induced lymphopenia, which may improve clinical outcomes.
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