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Enhanced chondrogenesis with upregulation of PKR using a novel hydrostatic pressure bioreactor
Jeonghyun Kim1, Kevin Montagne, Takashi Ushida
1a Department of Mechanical Engineering, Graduate School of Engineering , University of Tokyo , Tokyo , Japan.
Bioscience, Biotechnology, and Biochemistry
|October 29, 2014
Abstract:
In this study, we developed a novel bioreactor to load hydrostatic pressure to promote chondrogenesis of prechondrogenic ATDC5 cells in as little as 3 days. Furthermore, we showed that loading hydrostatic pressure induced the upregulation of PKR, which is known to participate in mechanotransduction in various models.
