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Expression of soluble triggering receptor expressed on myeloid cells-1 in childhood CF and non-CF bronchiectasis

R Masekela1, R Anderson, K de Boeck

  • 1Division of Pulmonology, Department of Paediatrics and Child Health, Steve Biko Academic Hospital, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.

Pediatric Pulmonology
|October 29, 2014
PubMed
Abstract

Insights

Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) levels are significantly higher in children with HIV-associated bronchiectasis compared to cystic fibrosis (CF) bronchiectasis. sTREM-1 correlates with neutrophilic inflammation in HIV-bronchiectasis and lung function in CF.

Area of Science:

  • Pulmonary Medicine
  • Immunology
  • Pediatrics

Background:

  • Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) shows potential as an inflammatory biomarker for acute infections in pulmonary conditions.
  • sTREM-1 expression is understudied in pediatric bronchiectasis, including cystic fibrosis (CF) and HIV-associated forms.

Purpose of the Study:

  • To investigate and compare sTREM-1 levels in children with HIV-associated bronchiectasis and CF-bronchiectasis.
  • To explore the correlation of sTREM-1 with inflammation markers and lung function in these pediatric populations.

Main Methods:

  • Induced sputum samples were collected from children with HIV-associated bronchiectasis and CF-bronchiectasis.
  • sTREM-1 levels were determined, and lung function parameters (FEV1, FVC) were measured.
  • Correlation analysis was performed between sTREM-1, inflammatory markers (IL-8, neutrophil elastase), and lung function.

Main Results:

  • sTREM-1 was detected in both groups, significantly higher in HIV-associated bronchiectasis (1244.0 pg/ml) than in CF-bronchiectasis (204.9 pg/ml).
  • In HIV-bronchiectasis, sTREM-1 positively correlated with IL-8 and sputum neutrophil elastase.
  • In CF, sTREM-1 strongly correlated with FVC% predicted and FEV1% predicted.

Conclusions:

  • Pulmonary innate immune functions appear overactive in HIV-associated bronchiectasis, indicated by higher sTREM-1 levels compared to CF.
  • sTREM-1 correlates with neutrophilic inflammation markers but not HIV disease activity.
  • In CF, sTREM-1 exhibits a negative correlation with pulmonary function parameters.
Keywords:
biomarkerexacerbationimmunodeficiencyinnate immunity

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