The miR-146a polymorphism and susceptibility to systemic lupus erythematosus and rheumatoid arthritis : a
1Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, 136-705, Seoul, Korea, lyhcgh@korea.ac.kr.
Objective:
The aim of this study was to explore whether the miR-146a polymorphism (rs2910164) confers susceptibility to systemic lupus erythematous (SLE) and rheumatoid arthritis (RA).
Methods:
A meta-analysis was conducted on the association of the miR-146a polymorphism with SLE and RA.
Results:
Five studies with 2013 patients and 2555 controls were included in the meta-analysis. Meta-analysis revealed no association between SLE and the miR-146a G allele (odds ratio, OR = 1.007, 95 % confidence interval, CI = 0.910-1.114, p = 0.888). Additionally, no associations were found between the miR-146a polymorphism and SLE using recessive or dominant models, or homozygote contrast. Meta-analysis using allele contrast, recessive and dominant models, as well as homozygote contrast failed to reveal an association between the miR-146a polymorphism and RA (OR for G allele = 1.114, 95 % CI = 0.892-1.391, p = 0.342).
Conclusion:
This meta-analysis demonstrates that the miR-146a polymorphism is not associated with susceptibility to SLE and RA. However, considering the small number of studies, further studies are needed to confirm this result.
Insights
This meta-analysis found no link between the miR-146a polymorphism and susceptibility to systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA). Further research is needed due to the limited number of studies included.
Area of Science:
- Genetics and Immunology
- Molecular Biology
Background:
- MicroRNA-146a (miR-146a) is implicated in immune regulation.
- Genetic variations, such as polymorphisms, in miR-146a may influence autoimmune disease susceptibility.
Purpose of the Study:
- To investigate the association between the miR-146a polymorphism (rs2910164) and the risk of developing systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).
Main Methods:
- A comprehensive meta-analysis was performed.
- Data from five studies, including 2013 patients and 2555 controls, were analyzed.
- Statistical models included allele contrast, recessive, dominant, and homozygote contrasts.
Main Results:
- No significant association was found between the miR-146a G allele and SLE susceptibility (OR = 1.007, p = 0.888).
- No associations were detected for miR-146a polymorphism with SLE under various genetic models.
- Similarly, no association was observed between the miR-146a polymorphism and RA risk (OR for G allele = 1.114, p = 0.342).
Conclusions:
- The miR-146a polymorphism (rs2910164) does not appear to be a significant risk factor for SLE or RA.
- The findings suggest that miR-146a genetic variations may not play a direct role in the pathogenesis of these autoimmune diseases.
- Larger, well-designed studies are recommended to validate these results and explore potential ethnic or environmental interactions.
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