Related Experiment Video
Updated: Apr 21, 2026
06:32
Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model
Published on: November 4, 2022
6.0K
[Metastasis in testis from prostate cancer]
Mike Allan Mortensen1, Birte Engvad, Louise Geertsen
1Urologisk Afdeling L, Odense Universitetshospital, Sdr. Boulevard 29, 5000 Odense. mike.allan.mortensen@rsyd.dk.
Ugeskrift for Laeger
|October 29, 2014
Summary
Prostate cancer rarely metastasizes to the testis. This case highlights ductal adenocarcinoma
Area of Science:
- Oncology
- Urology
Background:
- Prostatic adenocarcinoma is a common malignancy in older men.
- Testicular metastasis from prostate cancer is an infrequent occurrence.
Observation:
- An 89-year-old male with prostatic adenocarcinoma developed metastasis to the left testis.
- The patient underwent bilateral orchiectomy for treatment.
Findings:
- Histological examination revealed ductal adenocarcinoma.
- Immunohistochemistry confirmed positive markers for Prostate-Specific Antigen (PSA) and p501.
- Ductal adenocarcinoma subtype may correlate with an increased risk of testicular dissemination.
Implications:
- Testicular metastases in prostate cancer often indicate advanced disease and a poorer prognosis.
- This case underscores the importance of considering rare metastatic sites in advanced prostate cancer management.
Related Concept Videos
01:20Disorders of the Male Reproductive System
5.2K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
5.2K
01:27Testes: Histology
3.6K
A tough, fibrous membrane, the tunica albuginea, covers the testes, extending inward to form fibrous partitions or septa, dividing them into internal compartments called lobules. Each lobule has 1 to 3 tightly coiled seminiferous tubules where sperm production occurs. These tubules merge into a tubular network at the back of the testis, known as the rete testis. It connects to 15 to 20 efferent ductules, leading to the epididymis.
The spermatogenic cells, responsible for producing sperm, are...
The spermatogenic cells, responsible for producing sperm, are...
3.6K
02:30Metastasis
5.4K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.4K
01:15Sperm Transport
5.3K
The journey of sperm from its origin to the point of ejaculation begins within the seminiferous tubules of the testis. Here, Sertoli cells produce fluid that propels non-motile sperm through a series of conduits, starting with the straight tubules leading to the rete testis. This interconnected network of tubules acts as the initial pathway for sperm, guiding them into the efferent ductules and then into the epididymis for maturation.
The maturation phase occurs in the epididymis, where sperm...
The maturation phase occurs in the epididymis, where sperm...
5.3K
01:41Spermatogenesis
90.4K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
90.4K
01:26Testosterone: Functions and Regulation
3.2K
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
3.2K