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Analysis of amlodipine in serum by a sensitive high-performance liquid chromatographic method with amperometric
K Shimooka1, Y Sawada, H Tatematsu
1Department of Biochemistry, New Product Development Centre, Pfizer Taito Co. Ltd., Japan.
Journal of Pharmaceutical and Biomedical Analysis
|January 1, 1989
Abstract:
An analytical method for a new calcium channel blocking agent, amlodipine, has been developed using high-performance liquid chromatography with electrochemical detection. No compound modification is required for detection and the calibration curve in spiked sera is linear and reproducible over the range 0.2-2.0 ng ml-1. The method has been applied successfully to pharmacokinetics studies in rats and also can be used for other dihydropyridine compounds such as nifedipine and nicardipine.