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1Department of Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biosciences, University of California, San Francisco, California, 94158 USA. adam.abate@ucsf.edu.
Lab on a Chip
|October 30, 2014
Summary
We developed a novel gapped divider for fluorescence-activated droplet sorting, significantly increasing throughput. This advancement enables droplet microfluidics to operate over ten times faster than previous methods.
Area of Science:
- Microfluidics
- Biotechnology
- Analytical Chemistry
Background:
- Fluorescence-activated droplet sorting is crucial for microfluidic applications.
- Existing methods are limited to low throughputs (kilohertz range).
Purpose of the Study:
- To overcome throughput limitations in fluorescence-activated droplet sorting.
- To present a novel microfluidic device geometry for enhanced sorting speeds.
Main Methods:
- Introduction of a gapped divider in the droplet sorting outlet.
- Utilizing fluorescence detection for droplet sorting within a microfluidic chip.
Main Results:
- Achieved sorting speeds over ten times faster than conventional methods.
- Demonstrated a significant increase in throughput for droplet microfluidic workflows.
Conclusions:
- The gapped divider design is a breakthrough for high-throughput droplet microfluidics.
- This innovation has broad implications for various applications requiring rapid droplet analysis and sorting.
