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Updated: Apr 21, 2026

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans
Published on: December 11, 2016
[Rhabdomyolysis in a well-trained woman after unusually intense exercise]
Christian Larsen1, Mogens Pfeiffer Jensen
1Reumatologisk Afdeling U, Aarhus Universitets-hospital, Nørrebrogade 44, 8000 Aarhus C. christian.larsen@studmed.au.dk.
Abstract:
A 35-year-old woman was acutely hospitalized with oedema of the upper limbs, reduced force, severe movement reduction and muscle pain in both upper extremities. Her symptoms started after three days of intense exercise doing kayaking and a lot of pull-ups in crossfit. Rhabdomyolysis is a syndrome, characterized by muscle necrosis. Usually there is a marked elevation of creatine kinase (CK) concentration with symptoms as described and myoglobinuria (dark coloured urine). After hard muscular work there will often be asymptomatic, but significant elevations in CK concentration, and in rare cases life-threatening rhabdomyolysis with electrolyte imbalances and acute kidney failure.
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