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Updated: Apr 21, 2026

Small and Wide Angle X-Ray Scattering Studies of Biological Macromolecules in Solution

Small and Wide Angle X-Ray Scattering Studies of Biological Macromolecules in Solution

Published on: January 8, 2013

SASBDB, a repository for biological small-angle scattering data.

Erica Valentini¹, Alexey G Kikhney², Gianpietro Previtali¹

¹European Molecular Biology Laboratory, Hamburg Outstation, Notkestr. 85, Geb. 25a, 22603 Hamburg, Germany.

Nucleic Acids Research

|October 30, 2014

Summary

This summary is machine-generated.

The Small-Angle Scattering Biological Data Bank (SASBDB) provides a central, searchable repository for scattering data and models. This resource supports researchers studying macromolecular shapes using small-angle X-ray and neutron scattering techniques.

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Last Updated: Apr 21, 2026

Small and Wide Angle X-Ray Scattering Studies of Biological Macromolecules in Solution

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Published on: January 8, 2013

Combining X-Ray Crystallography with Small Angle X-Ray Scattering to Model Unstructured Regions of Nsa1 from S. Cerevisiae

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Online Size-exclusion and Ion-exchange Chromatography on a SAXS Beamline

Online Size-exclusion and Ion-exchange Chromatography on a SAXS Beamline

Published on: January 5, 2017

Area of Science:

Structural Biology
Biophysics
Biochemistry

Background:

Small-angle X-ray and neutron scattering (SAXS and SANS) are essential for determining the global structures of biological macromolecules in solution.
Advancements in instrumentation and computation have led to a surge in scattering data and publications.
A unified data repository is crucial for managing and accessing this growing volume of information.

Purpose of the Study:

To establish a global repository for experimental small-angle scattering (SAS) data and associated structural models.
To facilitate the accessibility and searchability of SAS data for the research community.
To support the development of a federated database system for biological SAXS and SANS.

Main Methods:

Development of the Small-Angle Scattering Biological Data Bank (SASBDB) website (www.sasbdb.org).
Creation of a comprehensive repository for freely accessible and searchable SAS experimental data.
Inclusion of relevant experimental conditions, sample details, and instrument characteristics with each data deposit.
Manual curation of deposited experimental data quality and model accuracy, with plans for automated integration.

Main Results:

SASBDB is now operational as a dedicated resource for biological SAS data.
The database offers freely accessible and fully searchable experimental data and models.
Deposited data includes comprehensive experimental and sample information.

Conclusions:

SASBDB addresses the critical need for a centralized repository for SAXS and SANS data.
The data bank enhances data discoverability and accessibility for structural biology research.
SASBDB is a foundational component of a future federated system for biological scattering data.