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Updated: Apr 21, 2026

A Multi-detection Assay for Malaria Transmitting Mosquitoes
Published on: February 28, 2015
Genetic polymorphisms in VIR genes among Indian Plasmodium vivax populations
Purva Gupta1, Veena Pande2, Aparup Das1
1National Institute of Malaria Research, Sector-8 Dwarka, New Delhi-110077, India.
Abstract:
The vir genes are antigenic genes and are considered to be possible vaccine targets. Since India is highly endemic to Plasmodium vivax, we sequenced 5 different vir genes and investigated DNA sequence variations in 93 single-clonal P. vivax isolates. High variability was observed in all the 5 vir genes; the vir 1/9 gene was highly diverged across Indian populations. The patterns of genetic diversity do not follow geographical locations, as geographically distant populations were found to be genetically similar. The results in general present complex genetic diversity patterns in India, requiring further in-depth population genetic and functional studies.
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