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Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
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A cartridge based sensor array platform for multiple coagulation measurements from plasma.

O Cakmak1, E Ermek, N Kilinc

  • 1Koç University, Mechanical Engineering, Rumeli Feneri Yolu, 34450 Sariyer, Istanbul, Turkey. ocakmak@gmail.com.

Lab on a Chip
|October 30, 2014
PubMed
Summary
This summary is machine-generated.

This study introduces a novel microfluidic cartridge with MEMS sensors for simultaneous blood coagulation tests, including activated Partial Thromboplastin Time (aPTT) and Prothrombin Time (PT). This low-cost, reliable system shows potential for point-of-care diagnostics.

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Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Sensor Technology

Background:

  • Coagulation testing is crucial for diagnosing and managing bleeding disorders.
  • Current methods for coagulation tests can be time-consuming and require specialized laboratory equipment.
  • There is a need for rapid, accurate, and portable diagnostic tools for coagulation analysis.

Purpose of the Study:

  • To develop and validate a microfluidic Lab-on-Chip (LoC) platform for simultaneous real-time measurement of multiple blood coagulation parameters.
  • To demonstrate a MEMS-based sensor array integrated into a disposable cartridge for Prothrombin Time (PT) and activated Partial Thromboplastin Time (aPTT) assays.
  • To evaluate the performance of the developed system using human and control plasma samples.

Main Methods:

  • A disposable microfluidic cartridge was designed with MEMS microcantilevers for remote actuation and optical readout.
  • The system utilizes a reader unit without electrical connections to the cartridge, enabling simple and low-cost disposable designs.
  • Coagulation was monitored by measuring changes in microcantilever oscillation phase shift due to plasma viscosity changes during clotting.
  • The cartridge channels were functionalized with dried reagents for PT and aPTT tests.

Main Results:

  • The MEMS-based sensor array successfully performed real-time PT and aPTT measurements on plasma samples.
  • Measurements from control plasma samples showed good agreement with manufacturer specifications and a commercial reference device.
  • The system achieved coefficients of variation (CV) of 7.28% for PT and 6.33% for aPTT.
  • Reproducible results were obtained using only 10 μl of plasma.

Conclusions:

  • The developed LoC platform with a MEMS sensor array offers a versatile and reliable method for simultaneous PT and aPTT testing.
  • The system's design, low sample volume requirement, and accurate results suggest significant potential for point-of-care coagulation diagnostics.
  • The wireless reader and disposable cartridge design enhance usability and reduce costs, paving the way for accessible coagulation monitoring.