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Related Experiment Video

Updated: Apr 21, 2026

Development of New Therapeutic Applications Using Microfluidics

Development of New Therapeutic Applications Using Microfluidics

Published on: October 1, 2007

Research highlights: micro-engineered therapies.

Janay Elise Kong¹, Soroush Kahkeshani, Ivan Pushkarsky

¹Department of Bioengineering, California NanoSystems Institute, Jonsson Comprehensive Cancer Center, University of California Los Angeles, 420 Westwood Plaza, 5121 Engineering V, Box 951600, Los Angeles, California 90095, USA. dicarlo@ucla.edu.

|October 30, 2014

Summary

This summary is machine-generated.

Microfluidic systems are advancing therapeutic applications by precisely filtering blood to remove pathogens and isolate rare cells. Microengineered gels also protect cells for novel cell-based therapies.

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Last Updated: Apr 21, 2026

Development of New Therapeutic Applications Using Microfluidics

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Using Micro-Electro-Mechanical Systems MEMS to Develop Diagnostic Tools

Published on: October 1, 2007

Area of Science:

Biomedical Engineering
Therapeutic Development
Microfluidics

Background:

Lab on a chip systems traditionally focused on diagnostics and analysis.
Emerging applications leverage micro-engineering for therapeutic interventions.
Microfluidic precision offers solutions for complex biological challenges.

Purpose of the Study:

To highlight recent advancements in microfluidic and micro-engineered systems for therapeutic applications.
To showcase methods for blood filtration and rare cell isolation using microfluidics.
To present microgel technology for enhanced cell-based therapies.

Main Methods:

Blood filtration using chemically-modified surfaces, including bioengineered lectins on magnetic particles and antibody-functionalized alginate films.
Isolation of rare, therapeutically relevant cells from blood.
Generation of microscale gels with controlled porosity and mechanical rigidity for cell encapsulation.

Main Results:

Demonstration of microfluidic approaches for pathogen and toxin removal from blood.
Successful isolation of specific rare cells with therapeutic potential.
Development of protective microgel niches for cell-based therapies, such as mesenchymal stem cells.

Conclusions:

Microfluidic and micro-engineered systems are crucial for developing innovative therapies.
Chemically functionalized surfaces and microgels enhance therapeutic efficacy and cell protection.
Future progress relies on advanced microstructured materials, precise separations, and integrated sensing/delivery systems.