Recent survey on nanosuspension: a patent overview

Area of Science:

• Pharmaceutical Science
• Materials Science
• Drug Delivery Systems

Background:

• Nanosuspensions offer significant potential as drug delivery systems.
• They are effective in improving the bioavailability of poorly soluble drugs.
• Nanosuspensions present a cost-effective and technically simple alternative to liposomes and other colloidal carriers.

Purpose of the Study:

• To review pharmaceutical preparation methods for nanosuspensions.
• To explore the diverse applications of nanosuspensions in drug delivery.
• To survey recent patents related to nanosuspension technology.

Main Methods:

• Literature review of research articles on nanosuspension preparation and application.
• Patent landscape analysis of published and granted patents.
• Synthesis of information on preclinical and clinical studies of marketed nanosuspensions.

Main Results:

• Nanosuspensions demonstrate wide applicability across various routes (oral, injectable, topical, etc.).
• They improve drug bioavailability, reduce dosage, minimize gastric irritation, and enhance intestinal adhesion.
• Over 100 patents have been published, indicating significant recent interest and development.

Conclusions:

• Nanosuspensions are a valuable tool for overcoming drug solubility and stability challenges.
• Their controlled particle size and surface properties enable site-specific drug action.
• This review enhances understanding of controlled drug delivery through nanosuspension technology.