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Published on: March 6, 2018
Study of shrinkage of cutaneous surgical specimens
Gonzalo Blasco-Morente1, Cristina Garrido-Colmenero, Israel Pérez-López
1Department of Dermatology, Unit of the Virgen de las Nieves Hospital Complex, Granada, Spain.
Background:
The assessment of discrepancies between surgical and histopathological measurements of specimens is important in order to avoid repeat surgery and unnecessary follow-ups.
Objectives:
The objective of this study was to quantify the degree, time and influential factors of shrinkage of cutaneous surgical specimens.
Methods:
Data of 111 patients were gathered on age, sex, localization, diagnosis and specimen width and length before surgical excision (in vivo), at 5 min postsurgery (ex vivo) and after 24 h of fixation in 10% buffered formalin (postfixation).
Results:
The length and width were significantly lower in the postfixation vs. in vivo specimens, with a mean shrinkage of 17.0% in the length (p < 0.01) and 9.5% in the width (p < 0.01). 81.8% and 92.3% of the total shrinkage in length and weight was observed between in vivo and ex vivo measurements. No significant differences were observed as a function of sex, age or diagnosis. A greater shrinkage in length between in vivo and postfixation was found in specimens from the trunk.
Limitations:
The most of the skin samples were diseased.
Conclusion:
The largest proportion of specimen shrinkage occurred within 5 min of its excision and the shrinkage was greater in specimens from the trunk.
