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Updated: Jan 3, 2026

Guided Differentiation of Mature Kidney Podocytes from Human Induced Pluripotent Stem Cells Under Chemically Defined Conditions
Published on: July 2, 2020
Concise review: different mesenchymal stromal/stem cell populations reside in the adult kidney
Stefania Bruno1, Giulia Chiabotto1, Giovanni Camussi2
1Departments of Molecular Biotechnology and Health Science and Medical Sciences, University of Torino, Torino, Italy.
Abstract:
During fetal life, mesenchymal stromal/stem cells (MSCs) surround glomeruli and tubules and contribute to the development of the renal interstitium by secretion of growth factors that drive nephron differentiation. In the adult, an MSC-like population has been demonstrated in different compartments of human and murine nephrons. After injury, these cells might provide support for kidney regeneration by recapitulating the role they have in embryonic life. In this short review, we discuss the evidence of an MSC presence within the adult kidney and their potential contribution to the turnover of renal cells and injury repair.
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