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Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
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Hepatitis B virus coinfection in human immunodeficiency virus-infected patients: a review

Hsin-Yun Sun1, Wang-Huei Sheng1, Mao-Song Tsai1

  • 1Hsin-Yun Sun, Wang-Huei Sheng, Chien-Ching Hung, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 10617, Taiwan.

World Journal of Gastroenterology
|October 31, 2014
PubMed

Insights

Hepatitis B virus (HBV) and human immunodeficiency virus (HIV) coinfection accelerates disease progression. Effective management includes vaccination, safe practices, and combination antiretroviral therapy (cART) for viral suppression.

Area of Science:

  • Hepatology
  • Virology
  • Immunology

Background:

  • Hepatitis B virus (HBV) is a major cause of liver disease globally.
  • Hepatocellular carcinoma (HCC) is a significant risk associated with chronic HBV.
  • Coinfection with human immunodeficiency virus (HIV) and HBV is prevalent, affecting approximately 10% of HIV-infected individuals worldwide.

Purpose of the Study:

  • To review the impact of HBV/HIV coinfection on disease progression.
  • To outline effective management strategies for coinfected patients.
  • To highlight challenges and potential improvements in HBV vaccination for HIV-infected individuals.

Main Methods:

  • Literature review of HBV/HIV coinfection epidemiology.
  • Analysis of clinical outcomes in coinfected patients.
  • Evaluation of current and novel HBV vaccination strategies.

Main Results:

  • HBV coinfection accelerates HIV progression and increases hepatotoxicity risk with cART.
  • HIV infection exacerbates HBV-related liver disease, including cirrhosis and end-stage liver disease.
  • Combination antiretroviral therapy (cART) can achieve long-term suppression of both HIV and HBV replication.

Conclusions:

  • Safe sex, sterile needle use, HBV vaccination, and cART are crucial for managing HBV/HIV coinfection.
  • Enhanced HBV vaccination strategies, including higher doses, are necessary to overcome HIV-related immunosuppression and improve vaccine immunogenicity.

Keywords:
Nucleoside reverse-transcriptase inhibitorSeroepidemiologySexually transmitted diseasesVaccinationViral hepatitis

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