Related Experiment Video
Updated: Apr 21, 2026

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
Published on: March 7, 2019
Hypertension drives parenchymal β-amyloid accumulation in the brain parenchyma
Celine Z Bueche1, Cheryl Hawkes2, Cornelia Garz3
1Department of Neurology, Otto-von-Guericke University Magdeburg, Germany ; German Center for Neurodegenerative Diseases (DZNE) Magdeburg, Germany.
Abstract:
There is substantial controversy regarding the causative role of amyloid β (Aβ) deposition in Alzheimer's disease (AD). The cerebrovasculature plays an important role in the elimination of Aβ from the brain and hypertension is a well-known risk factor for AD. In spontaneously hypertensive stroke-prone rats (SHRSP), an animal model of chronic arterial hypertension, cerebral small vessel disease (CSVD) leads to age-dependent parenchymal Aβ accumulation similar to that observed in AD. These data approve the neuropathological link between CSVD and AD, confirm the challenge that parenchymal Aβ deposition is a specific marker for AD and disclose the meaning of SHRSP as valid experimental model to investigate the association between hypertension, CSVD, and Aβ plaques.
Related Concept Videos
Alzheimer Disease ll: Pathophysiology
Alzheimer Disease l: Introduction
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
Cerebral Edema ll: Pathophysiology
Dementia l: Introduction
Parkinson Disease ll: Pathophysiology

