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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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One-step encapsulation and triggered release based on Janus particle-stabilized multiple emulsions.

Fuquan Tu1, Daeyeon Lee

  • 1Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA. daeyeon@seas.upenn.edu.

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Summary

Stable multiple emulsions are formed in one step using stimuli-responsive Janus particles. These emulsions release encapsulated contents when the pH is increased, offering controlled delivery applications.

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Area of Science:

  • Materials Science
  • Colloid and Surface Chemistry

Background:

  • Multiple emulsions offer advanced delivery systems but often require complex formation methods.
  • Stimuli-responsive materials provide tunable control over emulsion properties.

Purpose of the Study:

  • To demonstrate a one-step method for creating stable multiple emulsions.
  • To utilize stimuli-responsive amphiphilic Janus particles as novel emulsifiers.
  • To achieve controlled release of encapsulated substances from these emulsions.

Main Methods:

  • Synthesis and characterization of amphiphilic Janus particles.
  • One-step emulsification process to form multiple emulsions.
  • pH-induced destabilization and release studies.

Main Results:

  • Stable multiple emulsions were successfully formed in a single step.
  • Janus particles effectively stabilized the emulsions against coalescence.
  • Increasing the pH of the continuous phase triggered the release of the encapsulated material.

Conclusions:

  • Stimuli-responsive Janus particles are effective emulsifiers for one-step multiple emulsion formation.
  • pH-triggered release offers a facile method for controlled payload delivery.
  • This approach has potential applications in drug delivery and formulation science.