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SMOCs: supramolecular organizing centres that control innate immunity

Jonathan C Kagan1, Venkat Giri Magupalli1, Hao Wu1

  • 1Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts 02446, USA.

Nature Reviews. Immunology
|November 1, 2014
PubMed
Summary

Researchers propose supramolecular organizing centres (SMOCs) as key signalling hubs in innate immunity. These higher-order complexes enhance enzyme activation and signal amplification for effective host defence against pathogens.

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