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Related Experiment Video

Updated: Apr 21, 2026

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
09:09

Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection

Published on: March 14, 2019

8.7K

Ascorbic-acid Treatment for Progressive Bone Metastases After Radiotherapy: A Pilot Study.

Huriye Senay Kiziltan, Ayse Gunes Bayir, Murat Demirtas

    Alternative Therapies in Health and Medicine
    |November 2, 2014
    PubMed
    Summary

    Intravenous vitamin C (ascorbic acid, or AA) shows promise in treating bone metastases after radiotherapy. This pilot study found AA reduced pain by 55% and improved survival, with acceptable toxicity.

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    Area of Science:

    • Oncology
    • Integrative Medicine
    • Cancer Research

    Background:

    • Intravenous vitamin C (ascorbic acid, AA) has been linked to improved cancer survival rates.
    • AA demonstrates a cytotoxic effect within cancer cells.
    • Bone metastases are a common and debilitating complication of cancer.

    Purpose of the Study:

    • To investigate the efficacy of intravenous AA in managing bone metastases.
    • To assess the impact of AA on pain and survival in cancer patients with bone metastases.
    • To evaluate the safety and toxicity profile of AA in this patient population.

    Main Methods:

    • A pilot study involving 11 cancer patients with bone metastases unresponsive to standard treatments.
    • Patients received 2.5 g of AA intravenously over 1 hour, with 3-10 weekly applications post-radiotherapy.

    Related Experiment Videos

    Last Updated: Apr 21, 2026

    Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection
    09:09

    Treatment with Vancomycin Loaded Calcium Sulphate and Autogenous Bone in an Improved Rabbit Model of Bone Infection

    Published on: March 14, 2019

    8.7K
  • Pain and performance status were assessed using the Visual Analog Scale and ECOG Performance Scale.

    • Main Results:

    • A 55% mean reduction in pain was observed among participants receiving AA.
    • The median survival time for patients treated with AA was 10 months.
    • Reported toxicities included 40% grade-I gastrointestinal and 30% urinary toxicity.

    Conclusions:

    • Intravenous AA administration shows encouraging results for treating bone metastases following radiotherapy.
    • AA treatment appears to be well-tolerated, with manageable toxicity levels.
    • Further research is warranted to confirm these findings in larger studies.