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Related Experiment Video

Updated: Apr 21, 2026

Image-Guided Resection of Glioblastoma and Intracranial Implantation of Therapeutic Stem Cell-seeded Scaffolds
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Optimizing glioblastoma resection: intraoperative mapping and beyond.

Joseph A Osorio1, Manish K Aghi

  • 1Department of Neurological Surgery, University of California, 505 Parnassus Avenue, Room M779, San Francisco, CA 94143-0112, USA.

CNS Oncology
|November 4, 2014
PubMed
Summary

Maximal safe surgical resection of glioblastomas improves patient prognosis. Advanced imaging and intraoperative techniques aid surgeons in balancing maximal tumor removal with preserving neurological function.

Keywords:
MRIglioblastomamappingresectiontractography

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Area of Science:

  • Neurosurgery
  • Oncology
  • Radiology

Background:

  • Glioblastoma management involves surgery, chemotherapy, and radiation.
  • Extent of surgical resection is linked to patient prognosis.
  • Balancing resection extent with functional preservation is crucial for tumors in eloquent areas.

Purpose of the Study:

  • To review preoperative and intraoperative techniques for maximal safe glioblastoma resection.
  • To highlight methods that improve surgical outcomes in glioblastoma patients.

Main Methods:

  • Review of preoperative imaging: functional MRI and magnetoencephalography (MEG).
  • Review of intraoperative techniques: motor/language mapping, intraoperative MRI, 5-aminolevulinic acid (5-ALA).

Main Results:

  • Preoperative imaging like fMRI and MEG can guide surgical planning.
  • Intraoperative tools such as mapping, iMRI, and 5-ALA enhance maximal safe resection.
  • These techniques help surgeons achieve optimal tumor removal while minimizing neurological deficits.

Conclusions:

  • Advanced imaging and intraoperative techniques are essential for maximizing safe glioblastoma resection.
  • Utilizing these methods can improve patient outcomes and quality of life.