Related Experiment Video
Updated: Apr 21, 2026
Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases
Published on: March 11, 2016
Near-infrared fundus autofluorescence in multiple evanescent white-dot syndrome
Maurizio Battaglia Parodi1, Pierluigi Iacono, Bruno Falcomatà
1Department of Ophthalmology, University Vita-Salute, Scientific Institute San Raffaele, Milan - Italy.
Purpose:
To report the near-infrared fundus autofluorescence (NIR-FAF) pattern in 2 cases of multiple evanescent white-dot syndrome (MEWDS).
Methods:
Three consecutive patients with MEWDS underwent a complete ophthalmologic examination, including color photograph, blue-light fundus autofluorescence, NIR-FAF, fluorescein angiography, and indocyanine green angiography (ICGA). Main outcome measure was the identification of NIR-FAF pattern.
Results:
Fluorescein angiography showed patchy hyperfluorescence of the whitish dots. Indocyanine green angiography showed hypofluorescent spots throughout the examination. Blue-light fundus autofluorescence disclosed a speckled pattern without extension to the foveal area, whereas NIR-AF showed several hypoautofluorescent lesions involving also the fovea, which corresponded to the whitish dots visible on biomicroscopy and to the hypofluorescent lesions detectable on ICGA.
Conclusions:
Near-infrared fundus autofluorescence is characterized by hypoautofluorescent spots corresponding to the inflammatory lesions typical of MEWDS and can be considered as a valuable noninvasive technique to diagnose and monitor patients with MEWDS.
