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Convenient synthesis of N1-substituted orotic acid derivatives
Jeannette T Bowler1, Caitlin R Clausen1, Daniel J Blackburn1
1Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, CA 94132 USA.
Abstract:
A convenient and efficient method for the synthesis of N1-substituted orotic acid derivatives is reported. The synthetic route utilizes substituted maleimide as synthetic intermediate and takes only four simple steps from readily available starting materials. As a result, orotic acid derivatives with various alkyl and aromatic groups at N1 can be readily synthesized.
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