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Updated: Apr 21, 2026

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
Published on: September 26, 2022
Amalgam contact hypersensitivity lesion: an unusual presentation-report of a rare case
Bk Ramnarayan1, Pm Maligi2, T Smitha3
1Department of Oral Medicine, Diagnosis and Radiology, Dayananda Sagar College of Dental Sciences and Hospital, Bengaluru, Karnataka, India.
Abstract:
Amalgam or its components may cause Type IV hypersensitivity reactions on the oral mucosa. These amalgam contact hypersensitivity lesions (ACHL) present as white striae and plaques, erythematous, erosive, atrophic, or ulcerative lesions. Postinflammatory pigmentation in such lesions and pigmentation due to amalgam incorporation in the soft tissue have been reported in the literature. However, ACHL presenting primarily as a black pigmented lesion is extremely rare if not reported. The clinician should be aware of one such presentation of ACHL; we report a unique case of ACHL in a 30-year-old female with such a pigmented lesion in close contact with amalgam restorations. The lesion regressed considerably in a year after replacement of the restoration with posterior composites.
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