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Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice

Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice

Published on: November 18, 2022

Stem cell treatment for type 1 diabetes.

Ming Li¹, Susumu Ikehara¹

¹Department of Stem Cell Disorders, Kansai Medical University Hirakata City, Osaka, Japan.

Frontiers in Cell and Developmental Biology

|November 4, 2014

Summary

Type 1 diabetes mellitus (T1DM) management remains challenging. Tissue stem cells (TSCs) show promise for generating insulin-producing cells, offering a potential new avenue for T1DM treatment beyond current therapies.

Keywords:

autoantibodies autoimmune disease bone marrow transplantation tissue-derived-stem cell type 1 diabetes

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High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model

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Published on: August 16, 2019

Area of Science:

Endocrinology
Regenerative Medicine
Cell Biology

Background:

Type 1 diabetes mellitus (T1DM) is a chronic pediatric disease caused by beta cell loss, leading to insulin deficiency and hyperglycemia.
Chronic hyperglycemia in T1DM results in severe complications like nephropathy, neuropathy, and retinopathy.
Current treatments, including diet and insulin therapy, fail to fully replicate natural insulin secretion, while transplantation faces donor limitations.

Purpose of the Study:

To review recent advancements in Type 1 diabetes mellitus (T1DM) research.
To explore the therapeutic potential of tissue stem cells (TSCs) for T1DM treatment.
To summarize the efficacy of TSCs in generating insulin-producing cells.

Main Methods:

Literature review of recent studies on T1DM.
Analysis of research on various stem cell types, including embryonic stem cells, induced pluripotent stem cells, and tissue stem cells (bone marrow, adipose, cord blood).
Evaluation of studies demonstrating the capacity of TSCs to differentiate into insulin-producing cells.

Main Results:

Stem cells, particularly tissue stem cells (TSCs), demonstrate potential for differentiation into insulin-producing cells.
TSCs derived from bone marrow, adipose tissue, and cord blood are highlighted for their insulin-producing capacity.
This review consolidates current knowledge on TSCs as a viable cell-based therapy for T1DM.

Conclusions:

Tissue stem cells (TSCs) represent a promising therapeutic strategy for Type 1 diabetes mellitus (T1DM).
The ability of TSCs to generate insulin-producing cells offers a potential alternative to current management options.
Further research into TSCs could lead to novel treatments for T1DM, improving glucose control and reducing complications.