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Related Experiment Videos

PrP(C) from stem cells to cancer.

Séverine Martin-Lannerée1, Théo Z Hirsch1, Julia Hernandez-Rapp2

  • 1Toxicology, Pharmacology and Cellular Signaling, INSERM UMR-S1124 Paris, France ; Toxicology, Pharmacology and Cellular Signaling, Université Paris Descartes, Sorbonne Paris Cité, UMR-S1124 Paris, France.

Frontiers in Cell and Developmental Biology
|November 4, 2014
PubMed
Summary

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The cellular prion protein (PrP(C)) plays a key role in regulating stem cell self-renewal and differentiation. Its dysregulation is linked to cancer progression, particularly in tumor-initiating cells.

Area of Science:

  • Molecular Biology
  • Stem Cell Biology
  • Oncology

Background:

  • The cellular prion protein (PrP(C)) is the normal counterpart of the pathological scrapie prion protein (PrP(Sc)).
  • PrP(C) knockout mice exhibit normal development, but show impaired hematopoietic stem cell function.
  • PrP(C) is expressed in various stem cell types, influencing their behavior.

Purpose of the Study:

  • To review the current understanding of PrP(C)'s role in stem cell biology.
  • To explore the connection between PrP(C) function and cancer progression.
  • To highlight PrP(C)'s involvement in stemness and cancer cell proliferation.

Main Methods:

  • Review of existing scientific literature on PrP(C) and stem cells.
  • Analysis of data from PrP-null mice studies.
Keywords:
cancercell fate specificationcellular prion proteinprion infectionself-renewalstem cell

Related Experiment Videos

  • Examination of PrP(C) expression in various tumor types and stem cell populations.

    • Main Results:

    • PrP(C) regulates self-renewal and differentiation potential in diverse stem cell types.
    • PrP(C) is implicated in the fate restriction of embryonic stem cells.
    • Overexpression of PrP(C) is observed in various tumors, particularly in tumor-initiating cells.

    Conclusions:

    • PrP(C) is a critical regulator of stem cell function.
    • The dysregulation of PrP(C) contributes to cancer development and progression.
    • Targeting PrP(C) may offer therapeutic strategies for cancer treatment.