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Short and long sleep durations are both associated with increased risk of stroke: a meta-analysis of observational
1Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Internal Medicine, People's Hospital of Chibi City, Chibi, China.
Background:
There is uncertainty about the relationship between sleep duration and stroke risk.
Aim:
We aimed to clarify the relationship between sleep duration and risk of stroke by using epidemiological evidence.
Methods:
We searched MEDLINE and EMBASE to identify all studies that might be looking at the association between sleep duration and stroke, including both cohort and cross-sectional studies. Pooled hazard ratios (HRs) and odds ratios (ORs) were calculated through a random-effects model.
Results:
Our study included a total of 12 cohort studies and 6 cross-sectional studies. Pooled results from the cohort studies showed that short sleep duration was associated with a higher risk for stroke [HR, 1.13; 95% confidence interval (CI) 1.02-1.25], and that long sleep duration also increases the risk of having a stroke (HR, 1.40; 95% CI, 1.16-1.64). Results from cross-sectional studies confirmed the relationship between stroke and inappropriate sleep duration, either too little sleep or too much. For short sleep duration, the OR was 1.71 (1.39-2.02); for long sleep duration, the OR was 2.12 (1.51-2.73).
Conclusion:
Both short and long sleep durations have a significant association with higher risk of stroke.
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