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Rare Association: Chagas' Disease and Hypertrophic Cardiomyopathy

Carlos Alberto Pastore1, Nelson Samesima1, Horácio Gomes Pereira Filho1

  • 1Clinical Unit of Electrocardiography.

Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
|November 5, 2014
PubMed

Insights

This study reports a rare case of a 49-year-old woman with Chagas disease and concomitant hypertrophic cardiomyopathy (HCM). The overlapping electrocardiogram (ECG) findings in this patient highlight the diagnostic challenges posed by this uncommon dual diagnosis.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Medical Imaging

Background:

  • Chagas disease, caused by *Trypanosoma cruzi*, commonly affects the heart.
  • Hypertrophic cardiomyopathy (HCM) is a primary cardiac muscle disease.
  • Electrocardiogram (ECG) abnormalities are frequent in both conditions.

Observation:

  • A 49-year-old woman presented with ECG findings suggestive of right bundle-branch block and left anterior-superior fascicular block.
  • Unusual R wave progression in lead V1 and ST segment elevation in anterior leads (V2-V6) were noted.
  • Imaging confirmed the coexistence of Chagas disease and HCM.

Findings:

  • The patient exhibited overlapping ECG patterns characteristic of both Chagas disease and HCM.
  • The specific ECG findings, including R > R' in V1 and anterior ST elevation, were attributed to the rare co-occurrence of these pathologies.
  • This case underscores the diagnostic complexity arising from the simultaneous presence of Chagas disease and HCM.

Implications:

  • Recognizing the potential for overlapping ECG manifestations is crucial for accurate diagnosis in patients with Chagas disease.
  • This case highlights the importance of comprehensive cardiac evaluation when both Chagas disease and HCM are suspected or confirmed.
  • Further research into the specific ECG signatures of combined cardiac conditions may improve diagnostic strategies.

Keywords:
Chagas heart failureechocardiography, 3Delectrocardiographyhypertrophic cardiomyopathymagnetic resonance angiography

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