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Cancer resistance as an acquired and inheritable trait

Janne Koch1, Jann Hau2, Henrik Elvang Jensen3

  • 1Department of Experimental Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark Institute of Veterinary Pathology, Faculty of LIFE Sciences, University of Copenhagen, Frederiksberg, Denmark jako@sund.ku.dk.

Anticancer Research
|November 5, 2014
PubMed
Abstract

Insights

Researchers induced cancer resistance in mice, finding it inheritable to offspring for at least two generations. This heritable induced cancer resistance (HICR) phenomenon, observed with S180 cells, offers a novel insight into acquired immunity.

Area of Science:

  • Immunology
  • Genetics
  • Cancer Biology

Background:

  • Acquired resistance to cancer is a significant challenge in oncology.
  • Investigating mechanisms of inherited immunity could offer new therapeutic avenues.

Purpose of the Study:

  • To induce cancer resistance in mice and determine if it is heritable.
  • To characterize the spectrum and immunological basis of this inherited resistance.

Main Methods:

  • BALB/c mice were immunized with inactivated S180 cancer cells (frozen/thawed, irradiated, or cell-free ascitic fluid).
  • Progeny of immunized mice were assessed for cancer resistance.
  • Flow cytometry (FACS) analyzed peritoneal cell populations.

Main Results:

  • Induced cancer resistance was inheritable to offspring for at least two generations, termed heritable induced cancer resistance (HICR).
  • Resistance was only observed with S180 cell-derived materials, not other cell lines.
  • Resistant mice showed an increased fraction of macrophages and no signs of cancer.

Conclusions:

  • Heritable induced cancer resistance (HICR) is demonstrable and inheritable from S180 cell immunization.
  • The molecular basis is unknown but may involve epigenetic modifications.
  • This study presents the first evidence of acquired, inherited cancer resistance.
Keywords:
Inheritable cancer resistanceS180 sarcoma cellsepigenetic transmissionmacrophages

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