Optimal management of infrainguinal arterial occlusive disease
David J Pennywell1, Tze-Woei Tan1, Wayne W Zhang1
1Division of Vascular and Endovascular Surgery, Louisiana State University Health Shreveport, Shreveport, LA, USA.
Insights
Peripheral arterial disease (PAD) is a growing concern, particularly in aging populations. Effective management involves risk factor modification, antiplatelet therapy, and surgical interventions like endovascular revascularization or bypass surgery for limb salvage.
Area of Science:
- Vascular Surgery
- Cardiology
- Public Health
Background:
- Peripheral arterial occlusive disease (PAOD) is a significant health issue, exacerbated by an aging population in Western societies.
- PAOD presents risks of limb loss and is often associated with comorbidities like cardiovascular and cerebrovascular diseases.
Purpose of the Study:
- To review current knowledge on peripheral arterial disease (PAD).
- To summarize evidence-based medical and surgical therapies for infrainguinal arterial occlusive disease.
Main Methods:
- This is a review article.
- It synthesizes current literature on PAD and its treatment modalities.
Main Results:
- Risk factor modification and antiplatelet therapy are crucial for improving survival in PAD patients.
- Endovascular intervention is increasingly preferred for infrainguinal disease due to technological advancements.
- Lower extremity bypass surgery remains a vital option for limb salvage in select patients.
Conclusions:
- PAD management requires a comprehensive approach, including medical therapy and surgical interventions.
- Treatment decisions for infrainguinal arterial occlusive disease should consider patient risk and available therapeutic options.
Abstract:
Peripheral arterial occlusive disease is becoming a major health problem in Western societies as the population continues to age. In addition to risk of limb loss, the complexity of the disease is magnified by its intimate association with medical comorbidity, especially cardiovascular and cerebrovascular disease. Risk factor modification and antiplatelet therapy are essential to improve long-term survival. Surgical intervention is indicated for intermittent claudication when a patient's quality of life remains unacceptable after a trial of conservative therapy. Open reconstruction and endovascular revascularization are cornerstone for limb salvage in patients with critical limb ischemia. Recent advances in catheter-based technology have made endovascular intervention the preferred treatment approach for infrainguinal disease in many cases. Nevertheless, lower extremity bypass remains an important treatment strategy, especially for reasonable risk patients with a suitable bypass conduit. In this review, we present a summary of current knowledge about peripheral arterial disease followed by a review of current, evidence-based medical and surgical therapy for infrainguinal arterial occlusive disease.
More Related Videos
Related Concept Videos
Peripheral Artery Disease III: Interprofessional Care
Peripheral Artery Disease V: Postoperative Nursing Management
Aneurysm III: Interprofessional Care
Peripheral Artery Disease IV: Nursing Management
Atherosclerosis III: Management
Angina IV: Management


