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Related Experiment Video

Updated: Apr 21, 2026

The Deese-Roediger-McDermott DRM Task: A Simple Cognitive Paradigm to Investigate False Memories in the Laboratory

The Deese-Roediger-McDermott DRM Task: A Simple Cognitive Paradigm to Investigate False Memories in the Laboratory

Published on: January 31, 2017

Read-across approaches--misconceptions, promises and challenges ahead.

Grace Patlewicz¹, Nicholas Ball, Richard A Becker

¹DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE, USA.

|November 5, 2014

Summary

This summary is machine-generated.

Read-across is a valuable data gap-filling method in chemical regulations like REACH. This article clarifies its use, challenges, and future integration with biological approaches for better chemical safety assessment.

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Area of Science:

Toxicology
Chemical Regulation
Data Gap Filling

Background:

Read-across is a key data gap filling technique within category and analogue approaches.
It is widely used in regulatory programs like the EU's REACH and the OECD High Production Volume Programme.
Despite its utility, misconceptions persist regarding its application, justification, and acceptance.

Purpose of the Study:

To clarify the true representation and robust scientific justification of read-across.
To discuss existing challenges and issues in the application and acceptance of read-across.
To outline future efforts and biologically-oriented approaches for enhancing read-across, aligning with the Toxicity in the 21st Century vision.

Main Methods:

This article is a 'Food for Thought' piece, not a consensus report.
It discusses various aspects of read-across, including its justification, challenges, and future directions.
It aims to raise awareness and set the agenda for future initiatives.

Main Results:

Read-across applications face challenges in robust justification and consistent acceptance.
Future enhancements are expected to integrate more biologically-oriented approaches.
There is an ongoing effort to improve the understanding and application of read-across.

Conclusions:

Read-across is a crucial tool in chemical safety assessment, but requires clear understanding and robust justification.
Future advancements will likely involve integrating novel biological methods.
Further initiatives are needed to facilitate the proper and effective use of read-across in regulatory contexts.