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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
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Inappropriate left ventricular mass and poor outcomes in patients with angina pectoris and normal ejection fraction

Bao-Tao Huang1, Yong Peng, Wei Liu

  • 1Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.

Coronary Artery Disease
|November 6, 2014
PubMed

Insights

Inappropriate left ventricular mass is linked to higher adverse event rates in patients with angina and normal ejection fraction. This finding highlights a significant risk factor for cardiovascular events in this population.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Clinical Outcomes Research

Background:

  • Inappropriate left ventricular mass is linked to cardiac abnormalities.
  • Its predictive value for clinical outcomes in coronary artery disease (CAD) patients is not well-established.

Purpose of the Study:

  • To investigate the association between inappropriate left ventricular mass and clinical outcomes.
  • Focus on patients with angina pectoris and preserved ejection fraction.

Main Methods:

  • 1515 patients with angina and normal ejection fraction were analyzed.
  • Inappropriate left ventricular mass defined as actual/predicted mass ratio > 150%.
  • Primary endpoint: composite of death, myocardial infarction, or stroke; propensity matching used for comparison.

Main Results:

  • 18.3% of patients had inappropriate left ventricular mass.
  • Higher composite event rate in the inappropriate group (11.2% vs. 6.6%, P=0.010).
  • Inappropriate left ventricular mass independently predicted adverse events (aHR=1.59, P=0.035).

Conclusions:

  • Inappropriate left ventricular mass is an independent risk factor for adverse cardiovascular events.
  • This finding is significant for patients with angina and normal ejection fraction.
  • The results were validated in propensity-matched cohorts and traditional left ventricular hypertrophy definitions.
Abstract

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