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Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction
14:19

Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction

Published on: October 14, 2016

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Risk factors, clinical features, and outcomes of premature acute myocardial infarction

Qi Liu1, Rui-Juan Shi1, Yi-Man Zhang1

  • 1Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.

Frontiers in Cardiovascular Medicine
|December 19, 2022
PubMed

Insights

Premature acute myocardial infarction (AMI) is linked to unhealthy lifestyles. Despite this, premature AMI patients showed better survival rates than older patients, but poor prognosis was predicted by low LVEF, high NT-proBNP, and in-hospital MACCEs.

Area of Science:

  • Cardiology
  • Public Health
  • Epidemiology

Background:

  • Premature acute myocardial infarction (AMI) affects younger individuals, often linked to lifestyle factors.
  • Understanding risk factors and prognosis in premature AMI is crucial for targeted interventions.

Purpose of the Study:

  • To investigate risk factors, clinical features, and prognostic factors of premature AMI.
  • To compare outcomes between premature and non-premature AMI patients.

Main Methods:

  • Retrospective cohort study of 8,942 AMI patients (2011-2019).
  • Premature AMI defined as < 55 years (men) and < 65 years (women).
  • Data collected on demographics, lab tests, ECG, cardiac ultrasound, coronary angiography; primary endpoint: all-cause death.

Main Results:

  • 2,513 (28.1%) cases were premature AMI, predominantly male (79.8%).
  • Premature AMI group had higher prevalence of smoking, dyslipidemia, overweight, obesity, and family history of CHD.
  • Premature AMI patients had significantly better survival rates (HR 0.27) over 4.6 years follow-up.
  • Low LVEF (aHR 3.00), peak NT-proBNP (aHR 1.34), and in-hospital MACCEs (aHR 2.36) predicted poor prognosis.

Conclusions:

  • Younger AMI patients exhibit risk factors like smoking, dyslipidemia, and obesity.
  • Low LVEF, elevated NT-proBNP, and in-hospital MACCEs are predictors of poor prognosis in premature AMI.
Abstract

Keywords:
CADacute myocardial infarctionprematureprognosisrisk factors

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