Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Schizophrenia01:17

Schizophrenia

1.8K
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
1.8K
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

946
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
946
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

1.1K
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
1.1K
Depression: Overview01:18

Depression: Overview

1.1K
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
1.1K
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

2.5K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
2.5K
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

1.2K
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Concerns About Self-Safety or Own Emotional Regulation in the Home are Both Associated With Suicidal Ideation: A Risk Factor Warranting Research and Policy Attention.

Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists·2026
Same author

Putting Lived Experience at the Centre: A Critical Review of Multidisciplinary, Person-Centred Mental Health Care.

Journal of multidisciplinary healthcare·2026
Same author

Risk of all-cause and cause-specific mortality, and suicide attempt in people with anxiety and stress-related disorders: a systematic review, meta-analysis and meta-regression analysis of 165 studies.

World psychiatry : official journal of the World Psychiatric Association (WPA)·2026
Same author

Body dysmorphic symptoms in autism and attention-deficit hyperactivity disorder: A comorbidity study.

The Australian and New Zealand journal of psychiatry·2026
Same author

A Multi-Symptom Circuit Architecture of Obsessive-Compulsive Disorder.

medRxiv : the preprint server for health sciences·2025
Same author

Magnetoencephalography during a saccadic eye movement task in anorexia nervosa.

Psychiatry research·2025
Same journal

Still Treating Yesterday's Risk? Reconsidering Antiviral Use for Mild-to-Moderate COVID-19 Cases in a Broadly Immune Population.

The Medical journal of Australia·2026
Same journal

Striving for Racial Equity in Oral Cancer Research: A Case Study.

The Medical journal of Australia·2026
Same journal

Progressing Cross-Sector Collaboration for People With Eating Disorders and Higher Weight: Priority Actions From an Expert Roundtable Using a Modified Nominal Group Technique.

The Medical journal of Australia·2026
Same journal

Self-Poisoning With Prazosin and Its Off-Label Use in Australia, 2014-2024: Analysis of NSW Poisons Information Centre Data.

The Medical journal of Australia·2026
Same journal

Drivers of Vaccine Uptake for Aboriginal and Torres Strait Islander Children to Inform Tailored Strategies: A Qualitative Study Exploring Health Service Provider Perspective.

The Medical journal of Australia·2026
Same journal

Four Urgent Actions for the Rights to Culturally Safe Breastfeeding for Aboriginal and Torres Strait Islander Mothers and Babies to Breastfeed in Neonatal Intensive Care Environments.

The Medical journal of Australia·2026
See all related articles

Related Experiment Video

Updated: Apr 21, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

21.5K

Schizophrenia and depression.

Peter Bosanac1, David J Castle2

  • 1St Vincent's Hospital, Melbourne, VIC, Australia. peter.bosanac@svhm.org.au.

The Medical Journal of Australia
|November 6, 2014
PubMed
Summary
This summary is machine-generated.

Depression is common in schizophrenia and requires careful monitoring by general practitioners (GPs). Antidepressants may help persistent symptoms, but their use alongside antipsychotics needs consideration due to potential side effects.

More Related Videos

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

4.1K
Animal Models of Depression - Chronic Despair Model CDM
05:47

Animal Models of Depression - Chronic Despair Model CDM

Published on: September 23, 2021

7.4K

Related Experiment Videos

Last Updated: Apr 21, 2026

A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

21.5K
Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

4.1K
Animal Models of Depression - Chronic Despair Model CDM
05:47

Animal Models of Depression - Chronic Despair Model CDM

Published on: September 23, 2021

7.4K

Area of Science:

  • Psychiatry
  • General Practice
  • Clinical Psychology

Background:

  • Depressive symptoms frequently occur in individuals with schizophrenia.
  • These symptoms are often underrecognized by clinicians, despite their association with increased suicidality.
  • General practitioners (GPs) are pivotal in the initial assessment and ongoing management of schizophrenia patients.

Purpose of the Study:

  • To highlight the importance of recognizing and managing depression in schizophrenia.
  • To outline the role of GPs in monitoring depressive symptoms and associated risks.
  • To discuss the therapeutic options for depression in schizophrenia, including pharmacotherapy and collaborative care.

Main Methods:

  • Literature review on depression in schizophrenia.
  • Analysis of the role of primary care physicians (GPs) in patient management.
  • Discussion of pharmacological interventions and integrated care models.

Main Results:

  • GPs play a crucial role in assessing and monitoring depression in schizophrenia patients.
  • Collaboration with mental health services and non-government organizations can improve care.
  • Antidepressants, used with antipsychotics, show potential for persistent depressive symptoms, though side effects are a concern.

Conclusions:

  • Effective management of depression in schizophrenia requires a multi-faceted approach involving GPs and specialist services.
  • The role of antidepressants alongside antipsychotics warrants further investigation regarding efficacy and side effect profiles.
  • The independent efficacy of atypical antipsychotics for depressive symptoms in schizophrenia remains to be established.