Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discovery of a Thermostable Nigerose Phosphorylase for the Efficient Chemoenzymatic Radiosynthesis of a <i>S. aureus</i>-Targeted <sup>18</sup>F-Disaccharide.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same author

Evaluation of radiation damage effects of low-energy Auger and conversion electrons emitted by <sup>134</sup>Ce decay using a Monte Carlo method.

Scientific reports·2026
Same author

Tumor response and tolerability under fractionated x-ray irradiation in a mouse xenograft model.

Physics in medicine and biology·2026
Same author

Development and Interpretable Machine Learning-Based Prediction of Cardiovascular Disease Risk in Chinese COPD Patients: An Analysis of the CHARLS Database.

International journal of chronic obstructive pulmonary disease·2026
Same author

A Prodrug Strategy to Conditionally Trap Therapeutic Payloads for Improved Tumor Retention.

ACS central science·2026
Same author

Simultaneous super resolution and denoising in X-ray CT using deep learning.

Journal of X-ray science and technology·2026

Related Experiment Video

Updated: Apr 21, 2026

Electrophysiological Assessment of Murine Atria with High-Resolution Optical Mapping
08:19

Electrophysiological Assessment of Murine Atria with High-Resolution Optical Mapping

Published on: February 22, 2018

11.6K

Multipinhole collimator with 20 apertures for a brain SPECT application.

Tzu-Cheng Lee1, Justin R Ellin1, Qiu Huang2

  • 1Physics Research Laboratory, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California 94107.

Medical Physics
|November 6, 2014
PubMed
Summary

New 20 multipinhole (20-MPH) collimators significantly enhance photon detection efficiency for dopamine transporter (DaT) SPECT imaging. This advancement promises shorter scan times and improved diagnostic accuracy for conditions like Parkinson's disease.

More Related Videos

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator
10:48

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

9.1K
3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol
10:14

3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol

Published on: May 12, 2019

6.7K

Related Experiment Videos

Last Updated: Apr 21, 2026

Electrophysiological Assessment of Murine Atria with High-Resolution Optical Mapping
08:19

Electrophysiological Assessment of Murine Atria with High-Resolution Optical Mapping

Published on: February 22, 2018

11.6K
PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator
10:48

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

9.1K
3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol
10:14

3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol

Published on: May 12, 2019

6.7K

Area of Science:

  • Nuclear Medicine
  • Medical Imaging Technology
  • Radiopharmaceutical Science

Background:

  • Single Photon Emission Computed Tomography (SPECT) is crucial for brain imaging, particularly for diagnosing Parkinson's disease via dopamine transporter (DaT) imaging.
  • Conventional parallel-hole collimators in SPECT have limitations in detector sensitivity and signal collection efficiency.
  • Improving these efficiencies can lead to reduced scan times and lower radiation doses for patients.

Purpose of the Study:

  • To evaluate the potential of custom-designed 20 multipinhole (20-MPH) collimators to enhance photon detection efficiency in DaT SPECT imaging.
  • To compare the performance of 20-MPH collimators against traditional low-energy high-resolution (LEHR) parallel-hole collimators.
  • To assess the impact of 20-MPH collimators on imaging parameters such as scan time and signal-to-noise ratio.

Main Methods:

  • SPECT imaging was performed using a striatal phantom containing Iodine-123.
  • Camera recovery ratios of the specific binding ratio (SBR) were quantified for both 20-MPH and LEHR collimators.
  • Acquisition times were systematically compared between the two collimator types.

Main Results:

  • The 20-MPH collimators demonstrated a potential for over an order of magnitude enhancement in photon detection efficiency compared to conventional SPECT collimators.
  • A comparable SBR recovery ratio was achieved with 20-MPH collimators in two-thirds of the acquisition time (20 minutes) compared to LEHR collimators (30 minutes).

Conclusions:

  • The 20-MPH collimator represents a promising alternative to traditional LEHR collimators for DaT SPECT brain imaging.
  • This technology offers the dual benefits of reduced scan duration and potentially enhanced diagnostic accuracy.
  • Further adoption of 20-MPH collimators could significantly improve the efficiency and effectiveness of SPECT imaging for neurological disorders.