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Updated: Apr 21, 2026

A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix
Published on: January 4, 2017
Extracellular matrix assembly: a multiscale deconstruction
Janna K Mouw1, Guanqing Ou2, Valerie M Weaver3
1Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco.
Abstract:
The biochemical and biophysical properties of the extracellular matrix (ECM) dictate tissue-specific cell behaviour. The molecules that are associated with the ECM of each tissue, including collagens, proteoglycans, laminins and fibronectin, and the manner in which they are assembled determine the structure and the organization of the resultant ECM. The product is a specific ECM signature that is comprised of unique compositional and topographical features that both reflect and facilitate the functional requirements of the tissue.
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