Enteral supplements of a carbon monoxide donor CORM-A1 protect against cerebrovascular dysfunction caused by neonatal

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Jianxiong Liu1, Alexander L Fedinec1, Charles W Leffler1

  • 1Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|November 6, 2014
PubMed

Insights

Enteral carbon monoxide (CO) donor CORM-A1 supplements improved cerebrovascular function after seizures in piglets. This therapy protects against neurovascular injury by delivering CO, enhancing blood flow regulation.

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Pharmacology

Background:

  • Oxidative stress-induced cerebral blood flow dysregulation worsens seizure outcomes.
  • Carbon monoxide (CO) donors, like CORM-A1, possess antioxidant and cytoprotective effects.
  • Neonatal seizures can lead to significant neurovascular injury.

Purpose of the Study:

  • To determine if enteral CORM-A1 administration improves cerebrovascular outcomes in piglets experiencing bicuculline-induced seizures.
  • To investigate the effects of CORM-A1 on cerebral blood flow regulation and neurovascular unit integrity post-seizure.

Main Methods:

  • Newborn piglets received enteral CORM-A1 before or after induced seizures.
  • Carbon monoxide levels in cerebrospinal fluid and pial arteriole dilation were measured.
  • Intravital microscopy assessed postictal cerebral vascular responses to various vasodilators 48 hours after seizures.

Main Results:

  • Enteral CORM-A1 increased cerebrospinal fluid CO and dilated pial arterioles.
  • Seizures significantly reduced postictal vascular responses, indicating neurovascular injury.
  • CORM-A1 treatment improved postictal cerebral vascular responsiveness to vasodilators.

Conclusions:

  • Enteral CORM-A1 effectively delivers the cytoprotective mediator CO to the brain.
  • This therapeutic approach mitigates injury to endothelial and astrocyte components of cerebral blood flow regulation.
  • Enteral CORM-A1 represents a promising therapeutic strategy for improving cerebrovascular outcomes in neonatal seizures.

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