Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antimicrobial Proteins01:23

Antimicrobial Proteins

10.5K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
10.5K
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

74
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
74
Biological Methods for Microbial Control01:28

Biological Methods for Microbial Control

1.4K
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
1.4K
Inhibitors of Gram-positive Cell Wall Synthesis01:23

Inhibitors of Gram-positive Cell Wall Synthesis

146
Bacterial cell walls are typically rigid structures composed mainly of peptidoglycan, a mesh-like polymer that provides mechanical strength and maintains cell shape. The synthesis of peptidoglycan is a crucial process in bacterial growth and serves as a primary target for many antibiotics.Mechanism of Action of Beta-Lactam AntibioticsBeta-lactam antibiotics, such as penicillin, inhibit peptidoglycan synthesis in actively growing cells. These antibiotics share a characteristic four-membered...
146
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

1.3K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.3K
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

2.3K
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

UV-DDB as a Dynamic Regulator Linking Base Excision and Nucleotide Excision Repair via AAG Interaction.

International journal of molecular sciences·2026
Same author

Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor-Ligand Interactions.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Pyrazole-Based Transthyretin Kinetic Stabilizers Identified Using a Covalent Fluorescent Probe Assay for Selectivity Profiling in Human Serum.

Journal of medicinal chemistry·2025
Same author

Nanocorona-engineered gold nanostars orchestrate photothermal augmented immunotherapy and durable cancer vaccination.

Journal of nanobiotechnology·2025
Same author

Effects of Electromagnetic Field on Seed Germination, β-Amylase Activity, Total Protein Content, Water Uptake, and Growth of Wheat Seedlings (Triticum aestivum).

Bioelectromagnetics·2025
Same author

DNA repair and disease: insights from the human DNA glycosylase NEIL family.

Experimental & molecular medicine·2025

Related Experiment Video

Updated: Apr 21, 2026

Production and Testing of Antimicrobial Peptides and Their Mimics
10:32

Production and Testing of Antimicrobial Peptides and Their Mimics

Published on: April 10, 2026

345

Antimicrobial peptides: therapeutic potentials.

Su-Jin Kang1, Sung Jean Park, Tsogbadrakh Mishig-Ochir

  • 1Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 151-742, Korea.

Expert Review of Anti-Infective Therapy
|November 6, 2014
PubMed
Summary

Antimicrobial peptides (AMPs) show promise against drug-resistant bacteria but face development hurdles. Strategies like modifying properties and advanced delivery systems aim to overcome toxicity and cost issues for therapeutic use.

Keywords:
AMPs in drug developmentantimicrobial peptideslimitations of AMPsmultidrug resistancestrategies for new therapeutic drug

More Related Videos

Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization
10:13

Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization

Published on: August 11, 2018

12.1K
Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
08:08

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

25.3K

Related Experiment Videos

Last Updated: Apr 21, 2026

Production and Testing of Antimicrobial Peptides and Their Mimics
10:32

Production and Testing of Antimicrobial Peptides and Their Mimics

Published on: April 10, 2026

345
Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization
10:13

Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization

Published on: August 11, 2018

12.1K
Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
08:08

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

25.3K

Area of Science:

  • Microbiology and Pharmacology
  • Drug Discovery and Development

Background:

  • Rising multidrug-resistant pathogens necessitate novel antibiotic alternatives.
  • Antimicrobial peptides (AMPs) offer broad-spectrum activity and unique mechanisms against microbes.
  • Current AMPs face limitations in pharmaceutical development, including toxicity, stability, and high manufacturing costs.

Purpose of the Study:

  • To review the potential of antimicrobial peptides (AMPs) as alternatives to conventional antibiotics.
  • To identify challenges hindering the clinical application of AMPs.
  • To explore strategies for overcoming AMP limitations and enabling therapeutic development.

Main Methods:

  • Review of existing literature on antimicrobial peptides.
  • Analysis of challenges in AMPs' pharmaceutical development (toxicity, stability, cost).
  • Exploration of modification techniques and advanced delivery systems for AMPs.

Main Results:

  • AMPs exhibit desirable properties like broad-spectrum activity and low resistance development.
  • Significant obstacles remain, including toxicity, poor stability, and prohibitive manufacturing costs.
  • Several strategies, from chemical modifications to advanced drug delivery, show potential to mitigate these challenges.

Conclusions:

  • Antimicrobial peptides (AMPs) represent a promising therapeutic avenue against resistant pathogens.
  • Overcoming toxicity, stability, and cost barriers is crucial for clinical translation.
  • Innovative approaches in AMP modification and delivery are essential for developing viable antimicrobial therapies.