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A Murine Model of Subarachnoid Hemorrhage
Published on: November 21, 2013
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Bilateral subinternal limiting membrane hemorrhage in benzene toxicity
Bryan K Hong1, Anne E Baranano, Srinivas R Sadda
1Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California.
Retinal Cases & Brief Reports
|November 6, 2014
Summary
Polyamide exposure can cause vision loss due to subinternal limiting membrane hemorrhage, linked to benzene-induced aplastic anemia and thrombocytopenia. This case highlights a rare but serious ocular complication of industrial chemical exposure.
Area of Science:
- Ophthalmology
- Toxicology
- Hematology
Background:
- A 20-year-old male factory worker presented with bilateral central vision loss.
- Initial workup was for hematologic malignancy due to petechiae and fevers.
Observation:
- Clinical examination included color fundus photography and spectral domain optical coherence tomography (SD-OCT).
- SD-OCT revealed bilateral subinternal limiting membrane hemorrhages.
- Complete blood count showed pancytopenia and severe thrombocytopenia.
Findings:
- The ocular findings mimicked Valsalva retinopathy.
- Benzene, a byproduct of polyamide curing, is a known cause of aplastic anemia.
- Thrombocytopenia is associated with an increased risk of spontaneous subinternal limiting membrane hemorrhage.
Implications:
- This case underscores the potential for severe ocular complications from industrial chemical exposure.
- Early recognition of these hemorrhages in conjunction with hematologic abnormalities is crucial for diagnosis.
- Highlights the link between occupational exposures, hematologic disorders, and ophthalmologic manifestations.
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