Bilateral subinternal limiting membrane hemorrhage in benzene toxicity
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Updated: Apr 21, 2026

A Murine Model of Subarachnoid Hemorrhage
Published on: November 21, 2013
Bryan K Hong1, Anne E Baranano, Srinivas R Sadda
1Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California.
Purpose:
To report the clinical and spectral domain optical coherence tomography findings in a patient with bilateral central vision loss and a history of exposure to polyamides.
Methods:
The clinical presentation of the patient was documented with color fundus photographs and spectral domain optical coherence tomography. The patient was a 20-year-old male factory worker with no medical history who was initially admitted for workup of hematologic malignancy due to petechiae and fevers.
Results:
Optical coherence tomography revealed bilateral hemorrhages in the subinternal limiting membrane space resembling Valsalva retinopathy. Complete blood count revealed pancytopenia and marked thrombocytopenia.
Conclusion:
Heavy exposure to benzene, a byproduct of the polyamide-curing process, is known to cause aplastic anemia. Accompanying thrombocytopenia may increase the risk of spontaneous subinternal limiting membrane hemorrhage.
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