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Diabetic Retinopathy01:27

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DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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Quantification of Diabetes-induced Adherent Leukocytes in Retinal Vasculature
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Leukemia presenting as serous retinal detachment.

Adiel G Smith1, Nikolas J S London, Kristina Pao

  • 1*Mid Atlantic Retina, The Retina Service of Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania; †Retina Consultants San Diego, La Jolla, California; ‡Delaware Valley Retina, Lawrenceville, New Jersey; and §Department of Ophthalmology, Wake Forest University Eye Center, Winston-Salem, North Carolina.

Retinal Cases & Brief Reports
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Summary
This summary is machine-generated.

Acute leukemia can manifest as isolated serous retinal detachments, a rare initial sign of hematologic malignancy. Early recognition is crucial for timely diagnosis and treatment of leukemia.

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Area of Science:

  • Ophthalmology
  • Hematology
  • Oncology

Background:

  • Presents a case of bilateral serous retinal detachments.
  • Highlights the absence of other retinal vascular or ocular inflammatory signs.
  • Discusses the diagnostic challenge posed by isolated retinal findings.

Observation:

  • A patient exhibited isolated bilateral serous retinal detachments.
  • This ocular presentation was the initial manifestation of an underlying hematologic malignancy.
  • No other retinopathy or ocular inflammation was observed.

Findings:

  • The patient was diagnosed with acute leukemia.
  • Isolated serous retinal detachments can be the sole presenting sign of acute leukemia.
  • This underscores the importance of considering hematologic malignancies in such cases.

Implications:

  • Delayed diagnosis of leukemia can occur if serous retinal detachments are misdiagnosed.
  • Ophthalmologists should include leukemia in the differential diagnosis for unexplained serous retinal detachments.
  • Prompt evaluation can lead to earlier detection and management of potentially life-threatening hematologic conditions.