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Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...

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Related Experiment Video

Updated: Apr 21, 2026

Ganglioside Extraction, Purification and Profiling

Ganglioside Extraction, Purification and Profiling

Published on: March 12, 2021

GM1 and GM2 gangliosides: recent developments.

Blaine Bisel, Francesco S Pavone, Martino Calamai

Biomolecular Concepts

|November 6, 2014

Summary

This summary is machine-generated.

Gangliosides GM1 and GM2 are vital cell membrane components involved in signaling and metabolism. Emerging evidence links them to neurodegenerative diseases like Alzheimer's and Parkinson's, expanding beyond known gangliosidoses.

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Ganglioside Extraction, Purification and Profiling

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Sublimation of DAN Matrix for the Detection and Visualization of Gangliosides in Rat Brain Tissue for MALDI Imaging Mass Spectrometry

Sublimation of DAN Matrix for the Detection and Visualization of Gangliosides in Rat Brain Tissue for MALDI Imaging Mass Spectrometry

Published on: March 23, 2017

Area of Science:

Biochemistry
Cell Biology
Neuroscience

Background:

GM1 and GM2 gangliosides are crucial cell membrane constituents.
These molecules are integral to cellular signaling and metabolic processes.

Purpose of the Study:

To provide a conceptual overview of GM1 and GM2 gangliosides.
To discuss their fundamental biological roles and disease associations.
To highlight recent advancements in understanding their functions.

Main Methods:

Review of recent scientific literature.
Conceptual analysis of biological functions.
Integration of data from various methodologies including in vivo imaging and in silico simulations.

Main Results:

GM1 and GM2 gangliosides are essential for normal cell function.
Established roles in gangliosidoses (e.g., Tay-Sachs disease).
Growing evidence implicates GM1 in Alzheimer's and Parkinson's diseases.

Conclusions:

GM1 and GM2 gangliosides have diverse biological functions.
Their dysfunction is linked to a range of neurological disorders.
Advanced methodologies are enhancing our understanding of ganglioside roles.